       Document 0544
 DOCN  M9610544
 TI    Cutaneous manifestations of opportunistic infections in patients
       infected with human immunodeficiency virus.
 DT    9601
 AU    Tappero JW; Perkins BA; Wenger JD; Berger TG; Childhood and Respiratory
       Diseases Branch, Centers for Disease; Control and Prevention, Atlanta,
       Georgia 30333, USA.
 SO    Clin Microbiol Rev. 1995 Jul;8(3):440-50. Unique Identifier : AIDSLINE
       MED/96009219
 AB    Bacillary angiomatosis (BA) presents most commonly as a cutaneous
       disease and is caused by two organisms. Bartonella (Rochalimaea)
       henselae and Bartonella (Rochalimaea) quintana. Biopsy confirmation of
       cutaneous BA is essential because lesions can mimic nodular Kaposi's
       sarcoma in appearance. Although the vast majority of human
       immunodeficiency virus (HIV)-infected patients with BA have CD4
       lymphocyte counts of less than 100 cells per mm3, the disease responds
       well to antimicrobial therapy. Staphylococcus aureus is the most common
       bacterial skin pathogen affecting HIV-infected patients. The prevalence
       of skin disease due to S. aureus may be explained by high nasal carriage
       rates for the organism ( > or = 50%) and altered immune function in
       conjunction with an impaired cutaneous barrier. Herpes simplex virus
       causes mucocutaneous disease early in the course HIV infection and
       ulcerative lesions at any site in advanced HIV infection. Herpes zoster
       is common early in the course of HIV infection; recurrent and
       disseminated herpes zoster infections are characteristic of patients
       with advanced HIV disease. Acyclovir resistance is usually seen in
       patients with large, untreated, ulcerative lesions of herpes simplex
       virus and in patients with chronic, verrucous lesions of
       varicella-zoster virus. Cutaneous cryptococcosis, histoplasmosis, and
       coccidiomycosis are markers of disseminated disease and require biopsy
       confirmation. Scabies is easily diagnosed but may be atypical in
       presentation and difficult to eradicate in advanced HIV disease.
 DE    Angiomatosis, Bacillary/COMPLICATIONS/DIAGNOSIS/THERAPY  AIDS-Related
       Opportunistic Infections/*COMPLICATIONS/DIAGNOSIS/  THERAPY
       Dermatomycoses/*COMPLICATIONS/DIAGNOSIS/THERAPY  Human  HIV
       Infections/*COMPLICATIONS  Skin Diseases,
       Bacterial/*COMPLICATIONS/DIAGNOSIS/THERAPY  Skin Diseases,
       Viral/*COMPLICATIONS/DIAGNOSIS/THERAPY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

