       Document 0530
 DOCN  M9610530
 TI    Virological markers in cerebrospinal fluid are predictive of ovine
       lentivirus-associated subclinical encephalomyelitis.
 DT    9601
 AU    Brodie SJ; Bickle HM; DeMartini JC; United States Department of
       Agriculture, Agricultural Research; Service, Laramie, Wyoming
       82071-3965, USA.
 SO    Clin Immunol Immunopathol. 1995 Oct;77(1):14-8. Unique Identifier :
       AIDSLINE MED/96010048
 AB    Encephalomyelitis is a sequela to ovine lentivirus (OvLV) and human
       immunodeficiency virus infections. Examination of autopsy tissue from 38
       naturally infected asymptomatic sheep showed that 7 (18%) had
       subclinical neurological lesions characterized by perivascular and
       periventricular infiltrates of lymphocytes and histiocytes in the
       leptomeninges, cerebral white matter, choroid plexus, and/or cervical
       spinal cord. Intralesional histiocytes were shown to contain lentiviral
       capsid proteins or RNA. Infectious virus (2/7), viral proteins (4/7),
       and antiviral antibody (5/7) were only detected in cerebrospinal fluid
       (CSF) from animals with central nervous system (CNS) lesions associated
       with OvLV infection, suggesting that such virologic markers in CSF, when
       used concurrently, are predictive of pathologic changes specific to the
       CNS.
 DE    Animal  Antigens, Viral/CEREBROSPINAL FLUID
       Encephalomyelitis/*CEREBROSPINAL FLUID/DIAGNOSIS  RNA, Viral/CHEMISTRY
       Sheep  Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       Support, U.S. Gov't, P.H.S.  Visna/*CEREBROSPINAL FLUID  Visna-Maedi
       Virus/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

