       Document 0528
 DOCN  M9610528
 TI    Anti-cardiolipin antibodies are associated with anti-endothelial cell
       antibodies but not with anti-beta 2 glycoprotein I antibodies in HIV
       infection.
 DT    9601
 AU    Weiss L; You JF; Giral P; Alhenc-Gelas M; Senger D; Kazatchkine MD;
       Service d'Immunologie, Hopital Broussais, Paris, France.
 SO    Clin Immunol Immunopathol. 1995 Oct;77(1):69-74. Unique Identifier :
       AIDSLINE MED/96010055
 AB    HIV infection is associated with polyclonal increase in serum
       immunoglobulins and with elevated titers of serum antibodies to a
       variety of self antigens, including anti-phospholipid antibodies. In the
       present study, we found a high prevalence of 46.8% of serum IgG
       anticardiolipin antibodies (ACA) in a group of 111 unselected
       HIV-seropositive individuals. The presence of ACA was correlated with
       that of IgG antibodies to endothelial cells (AECA) but not with that of
       anti-beta 2 glycoprotein I antibodies, that were only found in 7.4% of
       the patients. The presence of IgG ACA was not associated with detectable
       lupus anticoagulant activity, nor with a history of thrombosis. Serum
       titers of ACA were not correlated with absolute numbers of circulating
       CD4+ cells. We found no relationship between the presence and titers of
       ACA, hypergammaglobulinemia, and serum titers of natural IgG
       autoantibodies to a panel of self antigens. Our results suggest that
       increased titers of ACA in HIV infection result from a biased expansion
       of B cell clones producing natural autoantibodies.
 DE    Adult  Aged  Autoantibodies/*IMMUNOLOGY  Cardiolipins/*IMMUNOLOGY
       Endothelium, Vascular/*IMMUNOLOGY  Female  Glycoproteins/*IMMUNOLOGY
       Human  HIV Infections/*IMMUNOLOGY  IgG/IMMUNOLOGY  Lupus Coagulation
       Inhibitor/BLOOD  Male  Middle Age  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

