       Document 0527
 DOCN  M9610527
 TI    Natural killer (NK) and lymphokine-activated killer (LAK) activities in
       a patient who recovered from cancer, and the characteristics of LAK
       cells generated from CD4-CD8- and CD8+ peripheral blood lymphocytes.
 DT    9601
 AU    Komatsu F; Kihara K; Blood Transfusion Service, School of Medicine,
       Tokyo Medical &; Dental University, Japan.
 SO    Clin Immunol Immunopathol. 1995 Oct;77(1):75-81. Unique Identifier :
       AIDSLINE MED/96010056
 AB    The natural killer (NK) and lymphokine-activated killer (LAK) activities
       of a patient who recovered from bladder transitional cell carcinoma were
       determined. The patient was diagnosed in 1980 and repeated several
       therapies until 1986. Since 1987, he has been in a tumor-free state.
       Recently, very high NK and LAK activities were found. The NK activity
       was recognized not only against the NK-sensitive cell line K562, but
       also against NK-unsensitive Raji and Daudi cell lines and against
       autotumor cell line H41. The percentage of CD16+ in peripheral blood
       lymphocytes (PBL) was 52.9%, the CD8+CD16+ was 26.3%, and the
       CD4-CD8-CD16+ was 26.6% (17.5, 5.4 and 12.1% in healthy blood donor
       (control), respectively). Because the patient had large numbers of
       CD4-CD8- cells in the PBL, CD4-CD8- LAK were generated from them. The
       CD4-CD8- LAK cells exhibited extremely high killer activity, whereas the
       CD8+ LAK cells generated from the CD8+ cells showed a low level of
       killer activity. These results suggest that the tumor-free condition of
       this patient may be related to these high killer activities. In this
       patient, several cytokines were also determined, although the results
       were not completely interpreted.
 DE    Bladder Neoplasms/*IMMUNOLOGY  Carcinoma, Transitional Cell/*IMMUNOLOGY
       Case Report  Cytokines/BLOOD  Cytotoxicity, Immunologic  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Human  Immunity, Cellular  Immunity, Natural
       Killer Cells, Lymphokine-Activated/*IMMUNOLOGY  Killer Cells,
       Natural/*IMMUNOLOGY  Lymphocyte Subsets/*IMMUNOLOGY  Male  Middle Age
       Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

