       Document 0482
 DOCN  M9610482
 TI    Increased number of CD4-CD8+ MHC class II-specific T cells in MHC class
       II-deficient mice.
 DT    9601
 AU    Marusic-Galesic S; Walden P; Department of Molecular Medicine, Institute
       Ruder Boskovic,; Zabreb, Croatia.
 SO    Immunology. 1995 Jul;85(3):442-6. Unique Identifier : AIDSLINE
       MED/96005836
 AB    Targeted disruption of the A beta-encoding gene of H2b mice abolishes
       major histocompatibility complex (MHC) class II expression and results
       in a failure to develop CD4+8- T cells. Besides this major effect, the
       lack of class II expression affects the level of T-cell receptor (TCR)
       and CD4 expression on differentiating thymocytes. Moreover, there is no
       class II-mediated negative selection of thymocytes. All this could
       result in TCR repertoire changes of the CD4-8+ T-cell subpopulation,
       which apparently develops normally in these mice. To test this
       hypothesis, the class II reactivity of CD4-8+ T cells from class
       II-deficient (class II0) mice was analysed. It was found that CD4-8+ T
       cells from class II0 but not from class II-expressing mice developed a
       significant level of cytotoxicity against class II-expressing target
       cells. These results demonstrate an influence of MHC class II molecules
       on the TCR repertoire of CD4-8+ T cells.
 DE    Animal  *Cytotoxicity, Immunologic  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Haplotypes  Histocompatibility Antigens Class II/GENETICS/*IMMUNOLOGY
       Lymphocyte Culture Test, Mixed  Major Histocompatibility Complex  Mice
       Mice, Inbred Strains  Receptors, Antigen, T-Cell/IMMUNOLOGY
       Spleen/IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

