       Document 0478
 DOCN  M9610478
 TI    Cytokine production by cats infected with feline immunodeficiency virus:
       a longitudinal study.
 DT    9601
 AU    Lawrence CE; Callanan JJ; Willett BJ; Jarrett O; Department of
       Veterinary Pathology, University of Glasgow,; Bearsden, UK.
 SO    Immunology. 1995 Aug;85(4):568-74. Unique Identifier : AIDSLINE
       MED/96030670
 AB    The immune responsiveness of cats naturally or experimentally infected
       with feline immunodeficiency virus (FIV) was studied. Peripheral blood
       mononuclear cells (PBMC) from naturally infected, symptomatic animals
       displayed depressed proliferation and interleukin-2 (IL-2) production in
       response to mitogens, which was accompanied by a significant increase in
       IL-1, IL-6 and tumour necrosis factor (TNF) production. Longitudinal
       studies were performed over a period of 4 years in experimentally
       infected animals. The responses of cells from these cats to concanavalin
       A (Con A) were consistently less than those from uninfected cats
       throughout the period but, owing to variation between cats, were
       significantly lower on only a few occasions. By contrast, the responses
       of cells to pokeweed mitogen (PWM) were severely affected and declined
       progressively throughout the 4-year period. In general, responses to Con
       A but not PWM could be restored by the addition of exogenous IL-2. The
       decline in immune responsiveness was concurrent with a decline in feline
       (f)CD4+ cells and an inversion in the CD4:CD8 ratio. Peak production of
       IL-1, IL-6 and TNF coincided with periods of depressed immune responses.
       Additionally, immunodeficient responses and elevated levels of
       proinflammatory cytokines were concurrent with the presence of clinical
       signs. We conclude that, like human immunodeficiency virus (HIV), FIV
       infection results in significant perturbation of the immune response.
       Responses to PWM appear to correlate with disease progression which
       suggests that the CD3 pathway is affected in the earlier stages of the
       disease and that additional activation pathways such as CD2 may not be
       affected until the animal enters the acquired immune deficient syndrome
       (AIDS) stage of the disease.
 DE    Animal  Cats  Concanavalin A/IMMUNOLOGY  Cytokines/*BIOSYNTHESIS
       Disease Progression  Feline Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY  *Immunodeficiency Virus, Feline
       Interleukin-1/BIOSYNTHESIS  Interleukin-2/BIOSYNTHESIS
       Interleukin-6/BIOSYNTHESIS  Leukocytes, Mononuclear/IMMUNOLOGY
       Longitudinal Studies  Pokeweed Mitogens/IMMUNOLOGY  Support, Non-U.S.
       Gov't  T-Lymphocyte Subsets/IMMUNOLOGY  Tumor Necrosis
       Factor/BIOSYNTHESIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

