       Document 0475
 DOCN  M9610475
 TI    Adoptive transfer of T lymphocytes to T-cell-depleted mice inhibits
       Escherichia coli translocation from the gastrointestinal tract.
 DT    9601
 AU    Gautreaux MD; Gelder FB; Deitch EA; Berg RD; Department of Microbiology
       and Immunology, Louisiana State; University Medical Center-Shreveport,
       Shreveport 71130-3932, USA.
 SO    Infect Immun. 1995 Oct;63(10):3827-34. Unique Identifier : AIDSLINE
       MED/96009734
 AB    Bacterial translocation is defined as the passage of viable bacteria
       from the gastrointestinal (GI) tract to extraintestinal sites, such as
       the mesenteric lymph node (MLN), spleen, liver, kidneys, and blood.
       Previously, we reported that depletion of CD4+ and/or CD8+ T cells
       promotes bacterial translocation from the GI tract to the MLN. In the
       present study, CD4+ and/or CD8+ T cells, harvested from donor mice, were
       adoptively transferred to mice previously depleted of T cells by
       thymectomy plus intraperitoneal injection of rat anti-mouse T-cell
       monoclonal antibodies. The adoptively transferred CD4+ and/or CD8+ T
       cells inhibited the translocation of Escherichia coli from the GI tract.
       Migration of the adoptively transferred T cells to the spleens and MLNs
       of the recipient mice was determined by utilizing Thy 1.1+ donor cells
       adoptively transferred into mice whose cells express the Thy 1.2 marker.
       These results provide further evidence of the importance of T cells in
       the host immune defense against bacterial translocation from the GI
       tract.
 DE    Animal  Antibodies, Monoclonal/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Escherichia coli/*PHYSIOLOGY  Female  Gastrointestinal
       System/*MICROBIOLOGY  *Immunotherapy, Adoptive  Mice  Mice, Inbred C57BL
       Movement  Rats  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

