       Document 0462
 DOCN  M9610462
 TI    Dapsone-induced methemoglobinemia: an anesthetic risk.
 DT    9601
 AU    Szeremeta W; Dohar JE; Children's Hospital of Pittsburgh, PA 15213, USA.
 SO    Int J Pediatr Otorhinolaryngol. 1995 Aug;33(1):75-80. Unique Identifier
       : AIDSLINE MED/96058174
 AB    Dapsone is used to treat several systemic inflammatory diseases, many of
       which have head and neck manifestations, such as leprosy, systemic lupus
       erythematosus, rhinosporidiosis, relapsing polychondritis, dermatitis
       herpetiformis, pemphigus vulgaris and bullous pemphigoid. It has also
       been recently used prophylactically alone or in combination against
       malaria and in AIDS patients against Pneumocystis carinii infections.
       This is significant to the otolaryngologist-head and neck surgeon since
       approximately 40% of AIDS patients will have head and neck
       manifestations. Thus, the likelihood that otolaryngologists will be
       treating patients who are taking dapsone regularly is significant. We
       present a case of a 16-year-old female who presented with a presumptive
       diagnosis of discoid lupus for biopsy confirmation of her disease.
       Induction of general anesthesia was complicated by methemoglobinemia, an
       uncommon side effect of dapsone. We will discuss recognition and
       prevention of this side effect, its potential anesthetic implications,
       complications and treatment.
 DE    Adolescence  Anesthesia, General/*ADVERSE EFFECTS  Case Report
       Dapsone/*ADVERSE EFFECTS/THERAPEUTIC USE  Female  Human  Lupus
       Erythematosus, Discoid/DRUG THERAPY  Methemoglobinemia/*CHEMICALLY
       INDUCED  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

