       Document 0460
 DOCN  M9610460
 TI    Temporal stability of acute stressor-induced changes in cellular
       immunity.
 DT    9601
 AU    Mills PJ; Haeri SL; Dimsdale JE; Department of Psychiatry, University of
       California, San Diego, La; Jolla 92103-0804, USA.
 SO    Int J Psychophysiol. 1995 Apr;19(3):287-90. Unique Identifier : AIDSLINE
       MED/96057785
 AB    This study examined the temporal stability of enumerative immune
       responses to acute psychosocial stress. Lymphocyte subsets were measured
       in 24 healthy male subjects at rest and following a speaking stressor on
       two occasions approximately six weeks apart. The speaking task caused
       significant increases in T-suppressor/cytotoxic cells, natural killer
       cells, T-cells, and total WBC and decreases in the T-helper/suppressor
       ratio. Baseline test-retest correlation's were statistically significant
       for all variables (r values = 0.40-0.90). With two exceptions (T-cells
       and T-suppressor/cytotoxic cells), speaking task values (absolute
       reactivity scores) were also statistically significant (r values =
       0.48-0.92). Baseline adjusted test-retest correlations were however
       generally less reliable, with only natural killer cells (r values >
       0.40), the T-helper/suppressor ratio (r = 0.60), and total WBC (r =
       0.48) showing statistical significance. The findings suggest that
       certain but not all cellular immune responses to acute stress are
       moderately stable over time.
 DE    Adult  CD4-CD8 Ratio  Human  Immunity, Cellular/*PHYSIOLOGY  Killer
       Cells, Natural/IMMUNOLOGY  Leukocyte Count  Lymphocyte Count  Male
       Stress, Psychological/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes, Cytotoxic/IMMUNOLOGY  T-Lymphocytes,
       Helper-Inducer/IMMUNOLOGY  Time Factors  CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

