       Document 0459
 DOCN  M9610459
 TI    Long-term renal and hematologic effects of uninephrectomy in healthy
       feline kidney donors.
 DT    9601
 AU    Lirtzman RA; Gregory CR; Veterinary Medical Teaching Hospital,
       University of California,; Davis 95616-8747, USA.
 SO    J Am Vet Med Assoc. 1995 Oct 15;207(8):1044-7. Unique Identifier :
       AIDSLINE MED/96014041
 AB    To assess long-term hematologic and renal effects associated with a
       solitary kidney, 16 healthy cats undergoing uninephrectomy for kidney
       donation between May 1987 and January 1991 were evaluated by use of
       physical examination, CBC, serum biochemical analysis, urinalysis, and
       urine protein:creatinine ratio. Results of preoperative CBC, serum
       biochemical analysis, and urinalysis were within reference limits in all
       donors. Median age at surgery and at follow-up evaluation was 34 and 72
       months, respectively. Mean (+/- SEM) interval between follow-up and
       uninephrectomy was 39.3 +/- 14.6 months. Postuninephrectomy hematocrit
       and RBC indices were within reference limits in 15 donors. One cat with
       chronic renal insufficiency had normocytic, normochromic,
       nonregenerative anemia. In 15 clinically normal donor cats, mean (+/-
       SEM) serum creatinine concentrations pre- and post-uninephrectomy were
       1.36 +/- 0.20 and 1.71 +/- 0.33 mg/dl, respectively (P = 0.0002);
       however, the clinical relevance of this statistical difference in serum
       creatinine is uncertain, because all values were within reference
       limits. In addition, urine-concentrating ability was maintained in 14
       donors, with urine specific gravity > or = 1.040. Two donors, including
       the cat with chronic renal insufficiency, produced dilute urine
       (specific gravity < or = 1.020) and had substantial proteinuria, with
       urine protein:creatinine ratios of 2.16 and 3.62, respectively. Mean
       urine protein:creatinine ratio in donor cats was not significantly
       different from that in an age- and sex-matched comparison group. Renal
       and erythropoetic function was clinically preserved in the group of
       donor cats within 2 to 5 years after uninephrectomy.(ABSTRACT TRUNCATED
       AT 250 WORDS)
 DE    Animal  Cats/*PHYSIOLOGY/SURGERY  Feline Acquired Immunodeficiency
       Syndrome/COMPLICATIONS  Female  Follow-Up Studies  Kidney/*PHYSIOLOGY
       Kidney Failure, Acute/ETIOLOGY/THERAPY/VETERINARY  Kidney Failure,
       Chronic/ETIOLOGY/PHYSIOPATHOLOGY/VETERINARY  Kidney Function
       Tests/VETERINARY  Leukemia Virus, Feline  Linear Models  Lymphoma,
       Diffuse/ETIOLOGY/VETERINARY  Male  Nephrectomy/ADVERSE
       EFFECTS/*VETERINARY  Retrospective Studies  Specific Pathogen-Free
       Organisms  Support, Non-U.S. Gov't  *Tissue Donors
       Urinalysis/VETERINARY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

