       Document 0458
 DOCN  M9610458
 TI    A maternal risk factor for mother-to-child HTLV-I transmission: viral
       antigen-producing capacities in culture of peripheral blood and breast
       milk cells.
 DT    9601
 AU    Yoshinaga M; Yashiki S; Oki T; Fujiyoshi T; Nagata Y; Sonoda S;
       Department of Gynecology and Obstetrics, Faculty of Medicine,; Kagoshima
       University.
 SO    Jpn J Cancer Res. 1995 Jul;86(7):649-54. Unique Identifier : AIDSLINE
       MED/96004849
 AB    We examined the relationship between productivity of HTLV-I
       antigen-positive cells in cultured peripheral blood mononuclear cells
       (PBMC) and breast milk mononuclear cells (BMMC) and the incidence of
       mother-to-child transmission of HTLV-I. Among 61 cases of HTLV-I carrier
       mothers, 17 cases were revealed to produce large numbers of HTLV-I
       antigen-positive cells (high HTLV-I antigen-producing mothers) whose
       positive rate was 9.6% in PBMC and 10.2% in BMMC, while the remaining 44
       cases produced small numbers of HTLV-I antigen-positive cells (low
       HTLV-I antigen-producing mothers) whose positive rate was 0.3% in PBMC
       and 0.5% in BMMC. The HTLV-I transmission rate among children born to
       the high HTLV-I antigen-producing mothers was 37.5% (6/16 children from
       11 mothers), while that of the low HTLV-I antigen-producing mothers was
       3.2% (1/31 children from 20 mothers). The transmission rate of HTLV-I
       was significantly different between high and low HTLV-I
       antigen-producing mothers (P < 0.05). However, there was no positive
       relationship between anti-HTLV-I antibody titers and productivity of
       HTLV-I antigen-positive cells (P = 0.11). These results suggested that
       mother-to-child transmission of HTLV-I might be influenced by a
       maternally determined factor to produce HTLV-I antigen-positive cells in
       PBMC and BMMC of HTLV-I carrier mothers.
 DE    Adult  Carrier State  Cells, Cultured  *Disease Transmission, Vertical
       Female  Human  HTLV-I/*ISOLATION & PURIF  HTLV-I Antigens/*ANALYSIS
       HTLV-I Infections/EPIDEMIOLOGY/*TRANSMISSION  Infant, Newborn
       Lymphocytes/VIROLOGY  Male  Milk, Human/VIROLOGY  Predictive Value of
       Tests  Pregnancy  Pregnancy Complications, Infectious/*VIROLOGY  Risk
       Factors  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

