       Document 0456
 DOCN  M9610456
 TI    Effects of glutamine on the immune system: influence of muscular
       exercise and HIV infection.
 DT    9601
 AU    Rohde T; Ullum H; Rasmussen JP; Kristensen JH; Newsholme E; Pedersen BK;
       Laboratory of Infectious Diseases, Copenhagen Muscle Research; Centre,
       Rigshospitalet, Denmark.
 SO    J Appl Physiol. 1995 Jul;79(1):146-50. Unique Identifier : AIDSLINE
       MED/96035491
 AB    Glutamine increased the proliferative response and the
       lymphokine-activated killer cell activity of blood mononuclear cells
       isolated from normal healthy subjects (n = 6) in a dose-dependent
       manner, with optimum at 0.3-1.0 mM. The relative fraction of CD3+, CD4+,
       CD8+, CD14+, CD16+, and CD19+ cells was not changed by glutamine at a
       concentration of 0.6 mM, except in the phytohemagglutinin-stimulated
       proliferation experiment where the fraction of CD4+, and therefore CD3+
       cells, increased. The natural killer cell activity was not influenced by
       glutamine. Human immunodeficiency virus (HIV)-seropositive subjects (n =
       8) who performed concentric bicycle exercise for 1 h at 75% of maximal
       O2 consumption had an overall lower phytohemagglutinin-stimulated
       proliferative response, compared with the HIV-seronegative control group
       (n = 7). The proliferation during exercise was lower in both the
       HIV-seropositive and the HIV-seronegative group. Addition of glutamine
       in vitro did not normalize the lower proliferation in the
       HIV-seropositive group or the attenuated proliferation seen during
       exercise in both groups.
 DE    Adult  Cell Division/DRUG EFFECTS  Cytotoxicity, Immunologic/DRUG
       EFFECTS  *Exertion  Glutamine/*PHARMACOLOGY  Human  HIV
       Infections/*PHYSIOPATHOLOGY  HIV Seronegativity/PHYSIOLOGY  HIV
       Seropositivity/BLOOD  Immune System/*DRUG EFFECTS/*PHYSIOPATHOLOGY
       Killer Cells, Lymphokine-Activated/DRUG EFFECTS/PHYSIOLOGY  Killer
       Cells, Natural/DRUG EFFECTS/PHYSIOLOGY  Male  Monocytes/CYTOLOGY/DRUG
       EFFECTS  Muscles/*PHYSIOLOGY  Osmolar Concentration
       Phytohemagglutinins/PHARMACOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

