       Document 0450
 DOCN  M9610450
 TI    HIV-mediated B-lymphocyte activation and lymphomagenesis.
 DT    9601
 AU    Monroe JG; Silberstein LE; Department of Pathology and Laboratory
       Medicine, University of; Pennsylvania School of Medicine, Philadelphia
       19104, USA.
 SO    J Clin Immunol. 1995 Mar;15(2):61-8. Unique Identifier : AIDSLINE
       MED/96044247
 AB    Non-Hodgkin's (1ii)lymphoma is an AIDS-defining event in a significant
       percent of U.S. patients infected with the human immunodeficiency virus
       (HIV). Advances in anti-retroviral treatment and management of
       opportunistic infection have been accompanied by an increase in the
       incidence of these lymphomas. In the immunocompromised state of patients
       late in the course of HIV infection, these lymphomas represent a
       complication of HIV infection that is associated with an extremely poor
       prognosis. Currently, there is little understanding of the pathogenesis
       of HIV-associated lymphomas, which are nearly exclusively of B-cell
       origin. Experimental data do not support HIV infection in these
       lymphomas. While some lymphomas show evidence of EBV infection, the
       majority do not. Polyclonal B-cell hyperactivity during the early phases
       of HIV infection argues that chronic B-cell stimulation may be the major
       process predisposing B-cells in the HIV-infected individual to malignant
       transformation. The mechanism of this stimulation of normal B cells and
       its relationship to AIDS-associated lymphomas remain poorly understood.
       In this review, we will summarize current information on HIV-associated
       B lymphoma and then discuss our views on the association and regulation
       of HIV-related hyperactivity on the pathogenesis of this lymphoma.
 DE    B-Lymphocytes/*IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY  Lymphocyte
       Transformation/*IMMUNOLOGY  Lymphoma, AIDS-Related/*IMMUNOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

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