       Document 0411
 DOCN  M9610411
 TI    Lethal shock is inducible by lipopolysaccharide but not by superantigen
       in mice with retrovirus-induced immunodeficiency syndrome.
 DT    9601
 AU    Aoki Y; Hiromatsu K; Arai T; Usami J; Makino M; Ishida H; Yoshikai Y;
       Laboratory of Host Defense, Nagoya University School of Medicine,;
       Japan.
 SO    J Immunol. 1995 Oct 1;155(7):3494-500. Unique Identifier : AIDSLINE
       MED/96015994
 AB    The retrovirus-induced murine AIDS (MAIDS) shares many features with
       human AIDS. Here, we examined the susceptibility of mice with MAIDS to
       staphylococcal enterotoxin-triggered shock. Following sensitization with
       D-galactosamine (D-Gal), mice with MAIDS were resistant to the otherwise
       lethal effect of superantigen staphylococcal enterotoxin A (SEA). Peak
       IL-2 levels in these mice after D-Gal/SEA challenge were 10-fold higher
       than those in uninfected controls, and concurrently, IL-10 levels rose
       markedly with reduction of circulating IL-1 and IFN-gamma. Treatment
       with neutralizing anti-IL-10 mAb before D-Gal/SEA challenge led to
       increased IFN-gamma levels in mice with MAIDS, and resulted in a
       dose-dependent mortality. In contrast, mice with MAIDS were more
       susceptible to the toxicity of bacterial endotoxin LPS than were
       uninfected controls. Administration of 100 micrograms LPS alone induced
       50% lethality in mice infected with MAIDS virus 8 wk previously but not
       in uninfected controls. Administration of 10 micrograms LPS caused acute
       shock in D-Gal-sensitized mice with MAIDS. Peak TNF-alpha levels in
       these mice after LPS challenge were increased more than 10-fold, whereas
       IL-10 levels were one-third of those after SEA challenge. Moreover,
       serum IFN-gamma was undetectable in uninfected controls and rose to 1063
       +/- 483 pg/ml in mice with MAIDS 4 h after LPS challenge. These results
       suggest that aberrant profiles of cytokine production are crucial in
       determining fatal outcome in these two types of septic shock in MAIDS.
 DE    Animal  Enterotoxins/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Interferon Type
       II/ANALYSIS  Interleukin-1/BLOOD  Interleukin-10/BLOOD
       Interleukin-2/BLOOD  Lipopolysaccharides/*ADMINISTRATION & DOSAGE  Mice
       Mice, Inbred C57BL  Murine Acquired Immunodeficiency
       Syndrome/*COMPLICATIONS/  IMMUNOLOGY  Shock/*CHEMICALLY
       INDUCED/IMMUNOLOGY/MORTALITY  Superantigens/*ADMINISTRATION &
       DOSAGE/IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

