       Document 0397
 DOCN  M9610397
 TI    Anticryptococcal activity of NK cell-enriched peripheral blood
       lymphocytes from human immunodeficiency virus-infected subjects:
       responses to interleukin-2, interferon-gamma, and interleukin-12.
 DT    9601
 AU    Horn CA; Washburn RG; Department of Internal Medicine, Bowman Gray
       School of Medicine,; Wake Forest University, Winston-Salem, North
       Carolina 27157, USA.
 SO    J Infect Dis. 1995 Oct;172(4):1023-7. Unique Identifier : AIDSLINE
       MED/96029370
 AB    Anticryptococcal activity of highly purified NK cells from patients with
       either early asymptomatic or late-stage human immunodeficiency virus
       (HIV) infection proved to be markedly impaired; activity was
       reproducibly restored to normal levels by in vitro addition of exogenous
       interleukin-12 (IL-12). For these highly purified NK cells, responses to
       IL-2 and interferon-gamma (IFN-gamma) among HIV-infected patients were
       variable, with only 2 of 8 exhibiting significant responses to IL-2 or
       IFN-gamma. In contrast, IL-2 and IFN-gamma consistently enhanced
       anticryptococcal activity of mixed lymphocyte populations, cells that
       more closely approximate the network likely to be operational in vivo.
 DE    Cell Separation/METHODS  Cryptococcosis/COMPLICATIONS/IMMUNOLOGY
       Cryptococcus/*IMMUNOLOGY  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY  Interferon Type II/*PHARMACOLOGY
       Interleukin-12/PHARMACOLOGY  Interleukin-2/PHARMACOLOGY
       Interleukins/*PHARMACOLOGY  Killer Cells, Natural/DRUG
       EFFECTS/*IMMUNOLOGY  Receptors, IgG/IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

