       Document 0395
 DOCN  M9610395
 TI    Detection of herpesvirus DNA by nested polymerase chain reaction in
       cerebrospinal fluid of human immunodeficiency virus-infected persons
       with neurologic disease: a prospective evaluation.
 DT    9601
 AU    Fox JD; Brink NS; Zuckerman MA; Neild P; Gazzard BG; Tedder RS; Miller
       RF; Department of Medical Microbiology, University College London;
       Medical School and Hospitals, United Kingdom.
 SO    J Infect Dis. 1995 Oct;172(4):1087-90. Unique Identifier : AIDSLINE
       MED/96029380
 AB    A nested polymerase chain reaction-based method was used prospectively
       to detect herpesvirus DNA in cerebrospinal fluid (CSF) from 111 patients
       with AIDS, 39 of whom had a suspected diagnosis of cytomegalovirus
       (CMV)-associated neurologic disease (patients with encephalopathy,
       polyradiculopathy, or peripheral neuropathy) and 72 who had alternative
       diagnoses. CSF from 24 (62%) of the patients with suspected
       CMV-associated disease had detectable CMV DNA compared with only 8 (11%)
       of the patients with other diagnoses. Varicella-zoster virus DNA was
       detected in CSF from 3 patients (2 with myelitis and 1 with
       encephalitis), all of whom had recent cutaneous zoster. No CSF specimen
       contained detectable herpes simplex virus type 1 DNA, and none of the
       patients with myelitis had detectable herpes simplex virus type 2 DNA in
       CSF. This study demonstrates a significant association between
       detectable CMV DNA in CSF and suspected CMV-associated neurologic
       disease in patients with AIDS.
 DE    Cytomegalovirus Infections/*CEREBROSPINAL FLUID/COMPLICATIONS  DNA,
       Viral/*CEREBROSPINAL FLUID  Female  Human  HIV Infections/*COMPLICATIONS
       Male  Nervous System Diseases/*VIROLOGY  Prospective Studies  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

