       Document 0391
 DOCN  M9610391
 TI    Mycobacterium avium complex in macaques with AIDS is associated with a
       specific strain of simian immunodeficiency virus and prolonged survival
       after primary infection.
 DT    9601
 AU    Mansfield KG; Pauley D; Young HL; Lackner AA; New England Regional
       Primate Research Center, Harvard Medical; School, Southborough,
       Massachusetts 01772-9012, USA.
 SO    J Infect Dis. 1995 Oct;172(4):1149-52. Unique Identifier : AIDSLINE
       MED/96029396
 AB    Mycobacterium avium complex (MAC) in simian immunodeficiency virus
       (SIV)-infected macaques is a frequent opportunistic infection that
       shares many features with the condition in human AIDS patients. A
       retrospective analysis of necropsies on 135 macaques with SIV-induced
       simian AIDS that received neither antiretroviral nor antimicrobial
       therapy revealed that 17% (23/135) were infected with MAC. MAC developed
       in 31.3% (21/67) of the animals inoculated with uncloned SIVmac251
       versus 1.9% (1/53) and 6.7% (1/15) of the animals inoculated with the
       molecular clones SIVmac239 and SIVmac239/316EM, respectively (P = .001).
       This is the first example in which the risk of infection with a specific
       opportunistic organism was affected by the infecting strain of
       immunodeficiency virus. In addition, animals with MAC had a longer mean
       survival after primary infection and lower CD4 cell counts at death than
       animals that did not develop this opportunistic infection. The
       SIV-inoculated macaque is a valuable model in which to study the
       pathogenesis of MAC in the immunocompromised host.
 DE    Abdomen/PATHOLOGY  Age Factors  Animal  Comparative Study  Female  Lymph
       Nodes/PATHOLOGY  Macaca  Male  *Mycobacterium avium  Opportunistic
       Infections/ETIOLOGY/*VETERINARY  Retrospective Studies  Simian Acquired
       Immunodeficiency Syndrome/COMPLICATIONS/*VIROLOGY  Species Specificity
       Support, U.S. Gov't, P.H.S.  Survival Analysis
       Tuberculosis/ETIOLOGY/*VETERINARY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

