       Document 0387
 DOCN  M9610387
 TI    Phenotypic and functional parameters of cellular immunity in a
       chimpanzee with a naturally acquired simian immunodeficiency virus
       infection.
 DT    9601
 AU    Kestens L; Vingerhoets J; Peeters M; Vanham G; Vereecken C; Penne G;
       Niphuis H; van Eerd P; van der Groen G; Gigase P; et al; Laboratory of
       Pathology-Immunology, Institute of Tropical; Medicine, Antwerp, Belgium.
 SO    J Infect Dis. 1995 Oct;172(4):957-63. Unique Identifier : AIDSLINE
       MED/96029361
 AB    The cellular immunologic and virologic status of a chimpanzee, naturally
       infected with a human immunodeficiency virus type 1 (HIV-1)-like
       lentivirus (SIVcpz-ant), was compared longitudinally with those of 3
       HIV-1-infected and 5 uninfected chimpanzees for a period of 49 months.
       Evidence of immune deficiency was not observed in the HIV-1-infected
       chimpanzees, nor could virus be isolated from plasma. Virus could be
       isolated from plasma of the SIVcpz-ant-infected chimpanzee, but clinical
       signs of immune deficiency were never observed. Absolute CD4+ cell
       counts remained relatively stable, but NK cells fluctuated significantly
       over time and tended to correlate inversely with the virus titer in
       peripheral blood. Although only CD8+ T cells were directly demonstrated
       to exert a suppressive effect on viral replication in vitro, the
       observed fluctuation of NK cells suggests that these cells may also be
       involved in the interaction with lentivirus infection in this species.
 DE    Animal  Animals, Laboratory  Antigens, CD3  Chimpansee troglodytes
       Cytotoxicity, Immunologic  CD4-Positive T-Lymphocytes  CD8-Positive
       T-Lymphocytes  Follow-Up Studies  HIV-1/CLASSIFICATION  *Immunity,
       Cellular  Killer Cells, Natural  Leukocytes, Mononuclear/VIROLOGY
       Lymphocyte Subsets  Lymphocyte Transformation  Male  Simian Acquired
       Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY/  *VETERINARY  Support,
       Non-U.S. Gov't  SIV/CLASSIFICATION/GROWTH & DEVELOPMENT/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

