       Document 0381
 DOCN  M9610381
 TI    Enhanced expression of novel CD57+CD8+ LAK cells from cats infected with
       feline immunodeficiency virus.
 DT    9601
 AU    Zhao Y; Gebhard D; English R; Sellon R; Tompkins M; Tompkins W;
       Department of Microbiology, Pathology and Parasitology, College; of
       Veterinary Medicine, North Carolina State University, Raleigh;
       27695-8401, USA.
 SO    J Leukoc Biol. 1995 Oct;58(4):423-31. Unique Identifier : AIDSLINE
       MED/96005076
 AB    As a model for lymphokine-activated killer (LAK) function in HIV
       infection, we studied LAK cells in cats infected with feline
       immunodeficiency virus (FIV), which causes an acquired immunodeficiency
       syndrome. Peripheral blood mononuclear cells cultured in concanavalin A
       and interleukin-2 developed LAK cytotoxicity against chronically
       FIV-infected CrFK cells and acutely infected CD4+ lymphocytes but not
       uninfected cells. LAK cells from FIV+ cats were more cytotoxic than LAK
       cells from uninfected cats. Enhanced FIV+ LAK cytotoxicity against
       feline leukemia virus-infected cells (FL74) suggested that the
       cytotoxicity was not antigen specific. Two-color fluorescence-activated
       cell sorter analysis and antibody depletion studies demonstrated that
       the majority of LAK cells and their progenitors were positive for both
       CD8 and CD57. The in vitro induction of dual positive CD8+CD57+ LAK
       cells was enhanced in FIV+ cats, as reported for HIV+ patients. These
       CD8+CD57+ LAK cells may play a role in maintaining the long asymptomatic
       stage of infection in FIV+ cats.
 DE    Animal  Antigens, CD57/*ANALYSIS  Antigens, Viral/IMMUNOLOGY  Cats
       Comparative Study  Cytotoxicity, Immunologic  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Disease Models, Animal  Epitopes  Feline
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Hematopoietic Stem
       Cells/IMMUNOLOGY  *Immunodeficiency Virus, Feline
       Interleukin-2/PHARMACOLOGY  Killer Cells,
       Lymphokine-Activated/*IMMUNOLOGY  Leukocytes, Mononuclear/DRUG
       EFFECTS/IMMUNOLOGY  Phenotype  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

