       Document 0373
 DOCN  M9610373
 TI    Successful T cell priming in B cell-deficient mice.
 DT    9601
 AU    Epstein MM; Di Rosa F; Jankovic D; Sher A; Matzinger P; Laboratory of
       Cellular and Molecular Immunology, National; Institute of Allergy and
       Infectious Diseases, National Institutes; of Health, Bethesda, Maryland
       20892, USA.
 SO    J Exp Med. 1995 Oct 1;182(4):915-22. Unique Identifier : AIDSLINE
       MED/96018791
 AB    B cells are an abundant population of lymphocytes that can efficiently
       capture, process, and present antigen for recognition by activated or
       memory T cells. Controversial experiments and arguments exist, however,
       as to whether B cells are or should be involved in the priming of virgin
       T cells in vivo. Using B cell-deficient mice, we have studied the role
       of B cells as antigen-presenting cells in a wide variety of tests,
       including assays of T cell proliferation and cytokine production in
       responses to protein antigens, T cell killing to minor and major
       histocompatibility antigens, skin graft rejection, and the in vitro and
       in vivo responses to shistosome eggs. We found that B cells are not
       critical for either CD4 or CD8 T cell priming in any of these systems.
       This finding lends support to the notion that the priming of T cells is
       reserved for specialized cells such as dendritic cells and that antigen
       presentation by B cells serves distinct immunological functions.
 DE    Animal  *Antigen Presentation  Antigen-Presenting Cells/*IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY  Cytokines/ANALYSIS  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       Fluorescent Antibody Technique  Immunoglobulins, mu-Chain/GENETICS
       *Lymphocyte Transformation  Male  Mice  Mice, Inbred C57BL  Mice, Mutant
       Strains  Schistosomiasis mansoni/IMMUNOLOGY  Skin Transplantation
       Support, U.S. Gov't, P.H.S.  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

