       Document 0359
 DOCN  M9610359
 TI    A reinvestigation of Maprounea triterpenes.
 DT    9601
 AU    Beutler JA; Kashman Y; Tischler M; Cardellina JH 2nd; Gray GN; Currens
       MJ; Wall ME; Wani MC; Boyd MR; Laboratory of Drug Discovery Research and
       Development, National; Cancer Institute, Frederick, Maryland 21702-1201,
       USA.
 SO    J Nat Prod. 1995 Jul;58(7):1039-46. Unique Identifier : AIDSLINE
       MED/96054076
 AB    Anti-HIV activity and the inhibition of phorbol ester receptor binding
       activity in two species of Maprounea were traced to small amounts of
       highly potent phorbol esters of the daphnane type. The triterpenes
       previously isolated from this genus were found to be devoid of
       biological activity when scrupulously purified. Four new triterpene
       esters were elucidated; two [3,4] were found in M. africana, while three
       [4,6,7] were found in M. membranacea. Nmr assignments have also been
       made for two previously known compounds [2,5] in this group.
 DE    Acetylation  Animal  Binding, Competitive/DRUG EFFECTS  Brain/DRUG
       EFFECTS/METABOLISM  Chromatography, High Pressure Liquid  Hydrolysis
       HIV/*DRUG EFFECTS  In Vitro  Mass Fragmentography  Nuclear Magnetic
       Resonance  Phorbol 12,13-Dibutyrate/PHARMACOLOGY  Plants,
       Medicinal/*CHEMISTRY  Rats  Reverse Transcriptase Inhibitors  Species
       Specificity  Triterpenes/*CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

