       Document 0358
 DOCN  M9610358
 TI    Chronic hypertrophic cranial pachymeningitis associated with HTLV-I
       infection.
 DT    9601
 AU    Kawano Y; Kira J; Department of Neurology, Faculty of Medicine, Kyushu
       University; 60, Fukuoka, Japan.
 SO    J Neurol Neurosurg Psychiatry. 1995 Oct;59(4):435-7. Unique Identifier :
       AIDSLINE MED/96029502
 AB    Two patients presenting with recurrent multiple cranial neuropathy
       showed diffuse thickening and gadolinium enhancement of the dura mater
       on brain MRI. Both had anti-HTLV-I antibodies in serum. A quantitative
       polymerase chain reaction study of the peripheral blood disclosed that
       the HTLV-I proviral DNA loads increased considerably in one case and
       moderately in the other. Both showed a spontaneous proliferation of
       peripheral blood lymphocytes as well as an increase in helper/inducer T
       cells. Neither had any other underlying infections or autoimmune
       diseases. Thus it is possible that hypertrophic pachymeningitis
       developed as a result of multiorgan involvement of HTLV-I infection in
       these patients.
 DE    Adult  Brain/PATHOLOGY  Case Report  Chronic Disease  Dura
       Mater/*PATHOLOGY  DNA, Viral/ANALYSIS  Human  HTLV-I
       Infections/*COMPLICATIONS/IMMUNOLOGY/VIROLOGY  Magnetic Resonance
       Imaging  Male  Meningitis/*COMPLICATIONS/PATHOLOGY  Middle Age
       Polymerase Chain Reaction  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

