       Document 0357
 DOCN  M9610357
 TI    Neurophysiological assessment of peripheral nerve and spinal cord
       function in asymptomatic HIV-1 infection: results from the UCMSM/Medical
       Research Council neurology cohort.
 DT    9601
 AU    Connolly S; Manji H; McAllister RH; Griffin GB; Loveday C; Kirkis C;
       Sweeney B; Sartawi O; Durrance P; Fell M; et al; Department of Clinical
       Neurophysiology, Massachusetts General; Hospital 02114, USA.
 SO    J Neurol. 1995 Jun;242(6):406-14. Unique Identifier : AIDSLINE
       MED/96044659
 AB    As part of the Medical Research Council prospective study of the
       neurological complications of HIV infection, neurophysiological tests of
       spinal cord and peripheral nerve function were recorded in a cohort of
       homosexual or bisexual men. The studies included motor and sensory nerve
       conduction studies, vibration perception thresholds, somatosensory
       evoked potentials and motor evoked potentials elicited by magnetic
       stimulation. The results were compared with markers of immune function.
       The findings from 114 volunteers were analysed in a cross-sectional
       study. Fifty-nine were HIV-seropositive but asymptomatic, 26 had
       progressed to the symptomatic stages of HIV disease and 29 were
       persistently HIV-seronegative. There was some evidence of a mild sensory
       axonopathy in the symptomatic HIV-seropositive group. No differences
       were detected between the asymptomatic HIV-seropositive group and the
       HIV-seronegative comparison group. There were no consistently
       significant correlations between the neurophysiological measurements and
       CD4 counts and beta 2-microglobulin levels. On repeated testing, there
       was no evidence of a trend towards deterioration over a mean period of
       approximately 3 years in 36 HIV-seropositive subjects who remained
       asymptomatic compared with 22 HIV-seronegatives. These findings have
       failed to demonstrate neurophysiological evidence of spinal cord or
       peripheral nerve dysfunction in the asymptomatic stages of HIV
       infection.
 DE    Adult  Case-Control Studies  Cross-Sectional Studies  Evaluation Studies
       Evoked Potentials, Motor/PHYSIOLOGY  Evoked Potentials,
       Somatosensory/PHYSIOLOGY  Human  HIV Seronegativity/*PHYSIOLOGY  HIV
       Seropositivity/*PHYSIOPATHOLOGY  *HIV-1  Male  Neural Conduction
       Peripheral Nerves/*PHYSIOPATHOLOGY  Prospective Studies  Spinal
       Cord/*PHYSIOPATHOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

