       Document 0347
 DOCN  M9610347
 TI    Treatment intensity and reduction in drug use for cocaine-dependent
       methadone patients: a dose-response relationship.
 DT    9601
 AU    Rosenblum A; Magura S; Foote J; Palij M; Handelsman L; Lovejoy M;
       Stimmel B; National Development and Research Institutes, Inc., New York,
       New; York 10013, USA.
 SO    J Psychoactive Drugs. 1995 Apr-Jun;27(2):151-9. Unique Identifier :
       AIDSLINE MED/96053692
 AB    This study examined the impact of treatment intensity on cocaine use.
       Seventy-seven cocaine-using methadone patients were enrolled in a
       six-month, structured, manual-driven, cognitive-behavioral treatment
       program. Sessions consisted of five individual and/or group sessions per
       week. At intake subjects showed extensive polydrug abuse, psychiatric
       comorbidity, criminal histories, and HIV risk behaviors. Treatment
       intensity was measured by dividing number of sessions attended into
       quartiles. Paired comparisons, within treatment quartiles, were made
       between subjects' intake and six-month self-reports of cocaine use.
       Subjects in quartiles two through four showed significant reductions in
       frequency of cocaine use at follow-up, with subjects who received the
       most treatment showing the greatest reductions in cocaine use. Bivariate
       and multivariate analyses showed that treatment sessions attended
       remained a strong predictor of reduction in cocaine use at follow-up,
       even after controlling for drug use at intake and background variables.
       The results indicate that there is a substantial treatment dose-response
       relationship.
 DE    Adult  *Cocaine  Cognitive Therapy  Dose-Response Relationship, Drug
       Female  Follow-Up Studies  Human  Male  Methadone/ADMINISTRATION &
       DOSAGE/*THERAPEUTIC USE  Middle Age  Multivariate Analysis  New York
       City  Socioeconomic Factors  Substance
       Dependence/COMPLICATIONS/EPIDEMIOLOGY/*REHABILITATION  Support, U.S.
       Gov't, P.H.S.  CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

