       Document 0345
 DOCN  M9610345
 TI    Influence of host genotype on progression to acquired immunodeficiency
       syndrome among children infected with human immunodeficiency virus type
       1.
 DT    9601
 AU    Just JJ; Abrams E; Louie LG; Urbano R; Wara D; Nicholas SW; Stein Z;
       King MC; School of Public Health, University of California, Berkeley,
       USA.
 SO    J Pediatr. 1995 Oct;127(4):544-9. Unique Identifier : AIDSLINE
       MED/96006269
 AB    OBJECTIVE: To study the role of host genotype in pediatric infection
       with human immunodeficiency virus type 1 (HIV-1) and progression to
       acquired immunodeficiency syndrome (AIDS). METHODS: Human leukocyte
       antigen (HLA) class II and complement C4 genotypes were determined by
       means of molecular genetic techniques for 243 black children born to
       HIV-1-infected mothers in New York City and San Francisco. Survival,
       cumulative incidences of opportunistic infections and encephalopathy,
       and rates of CD4+ T cell decline were compared in children of different
       genotypes. RESULTS: Among HIV-1-infected children, the HLA-DR3 haplotype
       (DRB1*0301-DQA1*0501-DQB1*0201) was associated with increased incidence
       of encephalopathy, faster rate of CD4+ cell decline, and death before 2
       years of age. Deletion of the C4A gene was independently associated with
       increased incidences of encephalopathy and early death. DPB1*0101 was
       associated with survival to at least 2 years of age. The presence of
       DQB1*0604 was associated with increased risk of HIV infection.
       CONCLUSIONS: These results are consistent with previously reported
       associations between HLA genotypes and faster progression to AIDS among
       HIV-infected adults. The DR3 haplotype and C4A deletion may reflect the
       same underlying mechanism of susceptibility in that the DR3 haplotype is
       in linkage disequilibrium with other C4A null alleles. In addition, the
       class II locus DPB1 may have an independent effect on survival.
 DE    Acquired Immunodeficiency Syndrome/*VIROLOGY  Alleles  Child  Child,
       Preschool  Comparative Study  CD4-Positive T-Lymphocytes  *Disease
       Progression  *Genotype  Haplotypes  Human  HIV
       Seropositivity/TRANSMISSION/*VIROLOGY  HIV-1/*ISOLATION & PURIF  HLA
       Antigens  Infant  Prospective Studies  Retrospective Studies  Risk
       Factors  Support, U.S. Gov't, P.H.S.  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

