       Document 0322
 DOCN  M9610322
 TI    Immunocytochemistry of Kaposi's sarcoma-like tumor cells from pigtailed
       macaques with simian AIDS.
 DT    9601
 AU    Tsai CC; Wu H; Meng F; Regional Primate Research Center, University of
       Washington,; Seattle, USA.
 SO    J Med Primatol. 1995 Jan;24(1):43-8. Unique Identifier : AIDSLINE
       MED/96015613
 AB    Some macaques infected with SRV-2 developed SAIDS and RF, a Kaposi's
       sarcoma (KS)-like tumor. We investigated the immunophenotypic markers of
       this SAIDS-associated retroperitoneal fibromatosis (RF). RF tumor is
       characterized by proliferation of spindle cells accompanying
       inflammatory cell infiltrates, fibroblasts, and endothelial cells. RF
       spindle cells in tumor tissues revealed several immunobiologic
       characteristics similar to vascular smooth-muscle cells or
       myofibroblasts based on positive immunoreactivity of smooth-muscle
       alpha-actin and desmin. The majority of cultured RF spindle cells also
       expressed specific markers for vascular smooth muscle. These results
       suggest that the RF spindle cells are derived from vascular
       smooth-muscle cells. Furthermore, RF tissues and cells were persistently
       infected with SRV-2, which may play an important role in viral etiology
       of AIDS-associated neoplasm in this macaque model.
 DE    Animal  Antibodies  Antibodies, Monoclonal  Cell Differentiation  Cell
       Division  Fibromatosis, Abdominal/ETIOLOGY/*PATHOLOGY  Human
       Immunohistochemistry  Intermediate Filament Proteins/ANALYSIS  Macaca
       nemestrina  Sarcoma, Kaposi's/ETIOLOGY/*PATHOLOGY  Simian Acquired
       Immunodeficiency Syndrome/*COMPLICATIONS  Support, U.S. Gov't, P.H.S.
       SIV/ISOLATION & PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

