       Document 0312
 DOCN  M9610312
 TI    Lentivirus infection in an African lion: a clinical, pathologic and
       virologic study.
 DT    9601
 AU    Poli A; Abramo F; Cavicchio P; Bandecchi P; Ghelardi E; Pistello M;
       Department of Animal Pathology, University of Pisa, Italy.
 SO    J Wildl Dis. 1995 Jan;31(1):70-4. Unique Identifier : AIDSLINE
       MED/96031303
 AB    In May 1991, clinical, pathologic, and virologic investigations were
       carried out on an 8-yr-old male lion (Panthera leo), with recurrent
       infections, in captivity with two lionesses in the Zoological Garden of
       Pistoia, Tuscany, Italy. The lion had severe pneumonia, neutropenia,
       thrombocytopenia, and an increase in blood urea nitrogen and
       creatininemia; in spite of therapy, it died within 3 months. At
       necropsy, the animal had a lymphoma and other lesions similar to those
       described in feline immunodeficiency virus-infected cats. We identified
       FIV gag-sequence using PCR amplification of lymph node tissues.
 DE    Animal  Animals, Zoo  Antibodies, Viral/BLOOD  Antigens,
       Viral/IMMUNOLOGY  Blood Urea Nitrogen  Blotting, Southern/VETERINARY
       Blotting, Western/VETERINARY  Case Report  Creatinine/BLOOD  DNA,
       Viral/ANALYSIS  *Feline Acquired Immunodeficiency
       Syndrome/COMPLICATIONS/VIROLOGY  Gene Products, gag/GENETICS
       Immunodeficiency Virus, Feline/GENETICS/*IMMUNOLOGY  Infectious
       Peritonitis Virus, Feline/IMMUNOLOGY  Lentivirus
       Infections/COMPLICATIONS/*VETERINARY/VIROLOGY  Leukemia Virus,
       Feline/IMMUNOLOGY  *Lions  Lymph Nodes/PATHOLOGY/VIROLOGY  Lymphoma,
       Small Lymphocytic/ETIOLOGY/VETERINARY  Male
       Neutropenia/ETIOLOGY/VETERINARY  Pneumonia, Lobar/ETIOLOGY/VETERINARY
       Polymerase Chain Reaction/VETERINARY  Support, Non-U.S. Gov't
       Thrombocytopenia/ETIOLOGY/VETERINARY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

