       Document 0233
 DOCN  M9610233
 TI    Treatment of visceral leishmaniasis in a patient with AIDS with antimony
       and gamma-interferon: remission and prevention of relapse by maintenance
       therapy with weekly pentamidine.
 DT    9601
 AU    Lustig V; Kager PA; Meenhorst PL; Department of Internal Medicine,
       Slotervaart Hospital, Amsterdam,; Netherlands.
 SO    Neth J Med. 1995 Aug;47(2):66-9. Unique Identifier : AIDSLINE
       MED/96028906
 AB    A 41-year-old AIDS patient with fever, nightly perspiration, diarrhoea,
       anaemia and leukopenia was diagnosed as having visceral leishmaniasis
       (VL). After 8 weeks of antimony treatment combined with
       gamma-interferon, given in 2 courses of 3 and 5 weeks, 12 weeks apart,
       the bone marrow revealed no parasites by microscopy and culture.
       Parasitic DNA could still be demonstrated by polymerase chain reaction.
       Weekly intravenous pentamidine maintenance therapy seemed to prevent
       relapses. Over time the patient was treated for disseminated M. avium
       infection, CMV retinitis, porphyria cutanea tarda and renal tubular
       acidosis. Ultimately he succumbed, 2.5 years after the diagnosis of VL
       and 4.5 years after the diagnosis of AIDS was established.
 DE    Adult  Antimony/*THERAPEUTIC USE  Antiprotozoal Agents/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/DIAGNOSIS/*THERAPY  Case Report
       Drug Administration Schedule  Drug Therapy, Combination  Human
       Interferon Type II/*THERAPEUTIC USE  Leishmaniasis,
       Visceral/DIAGNOSIS/*THERAPY  Male  Pentamidine/*THERAPEUTIC USE  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

