       Document 0228
 DOCN  M9610228
 TI    Papanicolaou smears in human immunodeficiency virus-seropositive women
       during follow-up.
 DT    9601
 AU    Heard I; Bergeron C; Jeannel D; Henrion R; Kazatchkine MD; Unite
       d'Immunopathologic, Hopital Broussais, Paris, France.
 SO    Obstet Gynecol. 1995 Nov;86(5):749-53. Unique Identifier : AIDSLINE
       MED/96036680
 AB    OBJECTIVE: To assess the outcome of cervical squamous intraepithelial
       lesions (SIL) in human immunodeficiency virus (HIV)-seropositive women.
       METHODS: Papanicolaou smears were followed-up prospectively in a group
       of 60 HIV-positive women every 6 months for 18 months. RESULTS: The
       cumulative incidence of SIL at 18 months was 9% in 27 women who
       presented with normal Papanicolaou smears at entry. In 33 women who
       initially presented with SIL, the rate of persistence of cervical
       lesions was 95% (18 of 19) in untreated patients and 61% (eight of 13)
       in women who underwent surgery. In women with low-grade SIL, the
       persistence or progression of cervical lesions was observed in 92% of
       the cases (12 of 13). No invasive cancer was observed during the 18
       months of the study period. CONCLUSION: Although the long-term outcome
       of SIL in this population remains unknown, our results emphasize the
       high rate of persistence of SIL and the relative inefficiency of
       conventional treatment in HIV-infected women. These findings contrast
       with the natural history of SIL in immunocompetent women.
 DE    Adult  Cervical Intraepithelial Neoplasia/COMPLICATIONS/*DIAGNOSIS/
       SURGERY  Cervix Neoplasms/COMPLICATIONS/*DIAGNOSIS/SURGERY  CD4
       Lymphocyte Count  Female  Human  HIV
       Seropositivity/*COMPLICATIONS/IMMUNOLOGY  *HIV-1  Prospective Studies
       Support, Non-U.S. Gov't  *Vaginal Smears  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

