       Document 0227
 DOCN  M9610227
 TI    Malignant transformation of nasopharyngeal lymphoid hyperplasia.
 DT    9601
 AU    Kieserman SP; Stern J; Department of Otolaryngology/Head and Neck
       Surgery, New York Eye; and Ear Infirmary, NY 10003, USA.
 SO    Otolaryngol Head Neck Surg. 1995 Oct;113(4):474-6. Unique Identifier :
       AIDSLINE MED/96011735
 AB    Lymphadenopathy and nasal obstruction are very common in the
       HIV-positive patient and may or may not reveal a nasopharyngeal tumor.
       Biopsy is warranted if there is evidence suggestive of lymphoma or other
       neoplastic disease. This would include progressive rapid enlargement
       observed on examination or CT scan, an asymmetric growth pattern, and
       evidence of invasion of normal anatomic boundaries. It is certain that
       not all cases of adenoid hypertrophy that occurs early in the course of
       HIV disease represent a malignancy. Further study is needed to determine
       the proper timing for nasopharyngeal biopsy in the HIV-positive
       population. As the life span of the HIV-positive patient increases, so
       may the incidence of malignant degeneration.
 DE    Adenoids/*PATHOLOGY  Case Report  Cell Transformation,
       Neoplastic/*PATHOLOGY  Hearing Loss, Partial/PATHOLOGY  Human
       Hyperplasia  Lymphoma, AIDS-Related/*PATHOLOGY  Lymphoma, Large-Cell,
       Immunoblastic/*PATHOLOGY  Male  Middle Age  Nasopharyngeal
       Neoplasms/*PATHOLOGY  Nasopharynx/*PATHOLOGY  Otitis Media with
       Effusion/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

