       Document 0222
 DOCN  M9610222
 TI    Can a specifically-aimed pathologic classification overcome the
       difficulties in defining HIV-associated lymphomas?
 DT    9601
 AU    Carbone A; Boiocchi M; Gloghini A; De Re V; Dolcetti R; De Paoli P;
       Barzan L; Bertola G; Rossi C; Morassut S; et al; Divisione di Anatomia
       Patologica, Istituto Nazionale di Ricovero; e Cura a Carattere
       Scientifico, Aviano.
 SO    Pathologica. 1995 Feb;87(1):4-13. Unique Identifier : AIDSLINE
       MED/96002328
 AB    High grade B-cell systemic lymphomas in HIV-infected patients exhibit
       pleomorphic features as well as some overlap between established
       histologic subtypes thus highlighting the difficulties in defining them
       precisely by making use of the classifications for non-Hodgkin's
       lymphomas (NHL) proposed before the AIDS epidemic. A series of
       HIV-associated systemic lymphomas including 114 NHL and 25 Hodgkin's
       disease (HD) cases were morphologically and immunopheno-genotypically
       investigated at the Centro di Riferimento Oncologico, Aviano, Italy
       during a period of nine years. The International Working Formulation
       (WF) for NHL, the updated Kiel Classification and, later, morphologic
       variants of high grade B-cell NHL have been adopted in order to obtain a
       more detailed and specific histopathologic description of HIV-associated
       lymphomas. As a consequence of morphologic data, and considering also
       pathogenetic aspects as derived from literature, we have attempted a
       pathological categorization of HIV-associated systemic lymphomas based
       on the recognition of two main groups: the blastic cell group and the
       anaplastic one, both including specific cytomorphologic subtypes with,
       possibly, aggressive HD subtypes within one of them. This categorization
       uses the WF, the updated Kiel system, and the morphologic variants of
       high-grade lymphomas, and provides a provisional category for cases with
       intermediate morphologic features. Thus other histologic subtypes, such
       as small noncleaved cell (Burkitt) and immunoblastic lymphomas, can be
       defined in a more accurate way. The clear-cut placement of anaplastic
       cell lymphomas, including anaplastic large cell (CD30/Ki-1+) lymphomas,
       including anaplastic large cell (CD30/Ki-1+) lymphomas and possibly a
       proportion of HD cases, emphasizes the need for their diagnostic
       differentiation from polymorphic blastic' cell lymphomas, immunoblastic
       ones in particular.
 DE    Human  Lymphoma, AIDS-Related/CLASSIFICATION/*PATHOLOGY  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

