       Document 0220
 DOCN  M9610220
 TI    Application of thin-section low-dose chest CT (TSCT) in the management
       of pediatric AIDS.
 DT    9601
 AU    Ambrosino MM; Roche KJ; Genieser NB; Kaul A; Lawrence RM; Department of
       Radiology, New York University Medical Center, NY; 10016, USA.
 SO    Pediatr Radiol. 1995;25(5):393-400. Unique Identifier : AIDSLINE
       MED/96058133
 AB    The aim of this study was to evaluate the usefulness of thin-section
       low-dose computed tomography (TSCT) in the management of children with
       AIDS, as chest radiographs (CXR) often fail to adequately explain the
       patients' clinical status. We performed 54 noncontrast TSCTs on 32
       children. The patients aged from 3 months to 14.6 years, were diagnosed
       as having bacterial pneumonia, lumphocytic interstitial pneumonitis
       (LIP), Pneumocystis carinii pneumonia (PCP), or Mycobacterium
       avium-intracellulare infection (MAI). The scans were correlated with the
       clinical diagnosis, T-lymphocyte-subset percentages, and p24-antigen
       levels. Subsegmental consolidations were seen in patients with LIP, PCP,
       and MAI, and as an isolated finding in those with only bacterial
       pneumonia. Ground-glass haziness was seen exclusively with acute PCP.
       Reticulonodular thickening was identified only in patients with LIP.
       Mosaic perfusion was seen with MAI, LIP, and pneumonia. The presence of
       adenopathy correlated with CD4+ T-cell subset percentages. The greatest
       value of CT in this study was in detecting new disease when chest films
       failed to correlate with a patient's clinical state, and in
       demonstrating acute/subacute disease in patients with severe baseline
       chest-film changes. Recurrent pneumonias may represent progression of
       smoldering disease, rather than true recurrent disease following
       complete clearing. Adenopathy with low CD4+ levels should suggest
       lymphoma or infection with MAI.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY
       Adolescence  AIDS-Related Opportunistic Infections/RADIOGRAPHY  Child
       Child, Preschool  CD4 Lymphocyte Count  Female  Human  Infant
       Lung/*RADIOGRAPHY  Lung Diseases/COMPLICATIONS/*RADIOGRAPHY  Lung
       Diseases, Interstitial/COMPLICATIONS/RADIOGRAPHY  Male  Mycobacterium
       avium-intracellulare Infection/COMPLICATIONS/  RADIOGRAPHY  Pneumonia,
       Bacterial/COMPLICATIONS/RADIOGRAPHY  Pneumonia, Pneumocystis
       carinii/COMPLICATIONS/RADIOGRAPHY  *Tomography, X-Ray Computed  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

