       Document 0211
 DOCN  M9610211
 TI    [Beta-2 microglobulin in cerebrospinal fluid in neurology]
 DT    9601
 AU    Beyne P; Lisovoski F; Got L; Ayache P; Delacoux E; Service de Biochimie,
       Hopital Beaujon, Clichy.
 SO    Presse Med. 1995 Jun 24;24(23):1071-4. Unique Identifier : AIDSLINE
       MED/96006402
 AB    OBJECTIVES: beta 2-microglobulin (beta 2-m) is a small molecular weight
       protein (11 800 Daltons) which can transudate into the cerebrospinal
       fluid (CSF) in the same manner than albumin. Intrathecal synthesis is a
       sign of local immuno-stimulation and is correlated with immunoglobulin
       G. The aim of this study was to ascertain the relationship between beta
       2-microglobulin levels in the CSF and neurological diseases. METHODS:
       beta 2-microglobulin was assayed in the CSF and blood using an
       immunoenzyme method in 64 patients with multiple sclerosis (n = 14),
       human immunodeficiency virus (HIV) infection (n = 5), meningitis (n =
       12) or a peripheral neurological disease (n = 10) and in 7 control
       subjects. RESULTS: There was no overall correlation between beta 2-m in
       the CSF and blood levels (r = 0.35). In controls, beta 2-m CSF and blood
       levels were respectively 0.94 +/- 0.22 and 1.46 +/- 0.83 mg/l. beta 2-m
       was significantly higher in the CSF of patients with meningitis and in
       the HIV positive patients (4 +/- 3.5 and 3.69 +/- 2.06 mg/l
       respectively) (p < 0.05). Type of meningitis (bacterial or
       non-bacterial) had no effect on the CSF level. For the HIV patients, the
       CSF/blood ratio for beta 2-m was similar to that in controls due to a
       rise in both blood and CSF. Finally, in patients with multiple
       sclerosis, there was no significant change in CSF level of beta 2-m.
       CONCLUSION: beta 2-microglobulin in cerebrospinal fluid was not found to
       be correlated with the neurological diseases studied and cannot be used
       as a diagnostic test.
 DE    beta 2-Microglobulin/*ANALYSIS/CEREBROSPINAL FLUID  Acquired
       Immunodeficiency Syndrome/*CEREBROSPINAL FLUID  Adolescence  Adult  Aged
       Cerebrospinal Fluid Proteins/ANALYSIS  English Abstract  Female  Human
       Male  Meningitis, Aseptic/CEREBROSPINAL FLUID  Meningitis,
       Bacterial/*CEREBROSPINAL FLUID  Meningitis, Viral/*CEREBROSPINAL FLUID
       Middle Age  Multiple Sclerosis/*CEREBROSPINAL FLUID  Peripheral Nervous
       System Diseases/CEREBROSPINAL FLUID  Reference Values  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

