       Document 0180
 DOCN  M9610180
 TI    [Progressive multifocal leukoencephalopathy in patients with AIDS.
       Findings with computerized tomography and magnetic resonance]
 DT    9601
 AU    Tartaglione T; Colosimo C; Antinori A; Vecchiet J; Vural M; Marano P;
       Istituto di Radiologia, Universita Cattolica del Sacro Cuore,; Roma.
 SO    Radiol Med (Torino). 1995 Jul-Aug;90(1-2):8-15. Unique Identifier :
       AIDSLINE MED/96008626
 AB    Progressive Multifocal Leukoencephalopathy (PML) is a subacute
       demyelinating opportunistic infection of the central nervous system
       which frequently occurs in AIDS. CT and MR, together with clinical and
       virological findings, can suggest a correct diagnosis in most cases,
       thus avoiding stereotactic biopsy which is too invasive considering the
       lack of therapy and the poor prognosis of this disease. In this study we
       reviewed the CT and MR findings of 16 proved AIDS-related PML cases. PML
       lesions appeared as hypodense on CT, hypointense on T1w, hyperintense on
       PDw and T2w MR images. CT was less sensitive than T2w MR images and
       underestimated the number of lesions and/or disease extent. On the basis
       of our findings during the progression of the lesions we observed two
       different patterns of PML presentation and evolution i.e., single and
       multifocal. Single lesions generally involve subcortical white matter
       (arcuate fibers) of parietal lobe and spread to the contralateral
       hemisphere across the corpus callosum; multiple patchy lesions can be
       localized variably in the cerebral hemispheres and also in the brainstem
       and cerebellar hemispheres.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  English
       Abstract  Female  Human  Leukoencephalopathy, Progressive
       Multifocal/COMPLICATIONS/  *DIAGNOSIS  Magnetic Resonance Imaging  Male
       Middle Age  Sensitivity and Specificity  Tomography, X-Ray Computed
       JOURNAL ARTICLE

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