       Document 0172
 DOCN  M9610172
 TI    In vivo cytotoxic T-lymphocyte induction may take place via CD8 T helper
       lymphocytes.
 DT    9601
 AU    Lasarte JJ; Sarobe P; Prieto J; Borras-Cuesta F; Universidad de Navarra,
       Facultad de Medicina, Departamento de; Medicina Interna, Pamplona,
       Spain.
 SO    Res Immunol. 1995 Jan;146(1):35-44. Unique Identifier : AIDSLINE
       MED/96053387
 AB    Immunization of mice with peptide constructs, consisting of a
       determinant recognized by T cytotoxic cells colinearly linked to a
       determinant recognized by T helper cells (TDc-TDh) was able to induce
       cytotoxic T lymphocytes in vivo. Interestingly, this induction could be
       achieved in the absence of adjuvant in non-depleted as well as in
       CD4(+)-cell-depleted BALB/c mice. In the latter case, induction took
       place simultaneously with the activation of CD8+ T helper cells specific
       for a TDh contained within the sequence of the TDc RIQRGPGRAFVTIGK from
       the immunodominant V3 loop of HIV1 gp120. The possible implications of
       these findings in HIV infection and AIDS disease are discussed.
 DE    Amino Acid Sequence/IMMUNOLOGY  Animal  Antibodies,
       Monoclonal/PHARMACOLOGY  *Cytotoxicity, Immunologic  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY  Female
       Interleukin-2/BIOSYNTHESIS  Mice  Mice, Inbred BALB C  Molecular
       Sequence Data  Peptides/IMMUNOLOGY  Receptors, Interleukin-2/IMMUNOLOGY
       Support, Non-U.S. Gov't  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  Viral
       Proteins/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

