       Document 0161
 DOCN  M9610161
 TI    [Primary HIV infection. Clinical and serologic characteristics]
 DT    9601
 AU    Sepulveda C; Thompson L; Castrillon MA; Hurtado C; Departamento de
       Medicina, Hospital Jose Joaquin Aguirre,; Santiago de Chile.
 SO    Rev Med Chil. 1995 Jan;123(1):74-80. Unique Identifier : AIDSLINE
       MED/96054122
 AB    An acute clinical picture of variable intensity may occur during the
       initial primary phase of HIV infection, it may however pass unnoticed.
       We report 12 seronegative subjects (11 male homosexuals, 1 female
       heterosexual, aged 18 to 44 years old), that presented an acute clinical
       picture preceding seroconversion. All had a sudden beginning, resembling
       an acute mononucleosis in 10 and with an aseptic meningitis in two.
       Intensity and duration were variable, lasting a mean of 14 (range 5-44)
       days an remaining asymptomatic thereafter. Most patients presented a
       discrete leukopenia with lymphopenia at the expense of CD4 lymphocytes,
       followed by an absolute lymphocytosis in some, with an increase in CD8
       lymphocytes. All became positive for HIV; circulating HIV antigen was
       identified in three and IgM anti-HIV antibodies were detected during the
       symptomatic period by third generation ELISA in other three. It is
       concluded that the clinical picture of primary HIV infection has
       identifiable clinical serological and immunological features and its
       recognition has diagnostic and preventive implications.
 DE    Adolescence  Adult  AIDS Serodiagnosis  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  English
       Abstract  Female  Follow-Up Studies  Human  HIV
       Infections/DIAGNOSIS/*IMMUNOLOGY  Male  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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