       Document 0159
 DOCN  M9610159
 TI    The association of the platelet count and the peripheral CD8+ cell count
       in Japanese HIV-infected hemophiliacs.
 DT    9601
 AU    Ohji T; Tokumaru O; Urano H; Matsuda S; Shirahata A; Department of
       Pediatrics, School of Medicine, University of; Occupational and
       Environmental Health, Japan.
 SO    Sangyo Ika Daigaku Zasshi. 1995 Sep 1;17(3):155-63. Unique Identifier :
       AIDSLINE MED/96058364
 AB    To determine the factors involved in the pathogenesis of
       thrombocytopenia frequently found in human immuno-deficiency virus (HIV)
       infection, we studied the clinical and laboratory findings of 35
       Japanese HIV-infected hemophiliacs regarding their association with
       thrombocytopenia. Seventeen HIV-positive patients were thrombocytopenic.
       They had fewer CD4+ cells and were in more advanced stages of the
       disease, compared with the 18 patients without thrombocytopenia. We
       carried out the stepwise regression analysis on 32 patients in the early
       stage of HIV infection, with the platelet count as the dependent
       variable, and with the CD8+ cell count, serum cholinesterase, alanine
       aminotransferase (ALT), CD4+ cell count and white blood cell count as
       explanatory variables. The CD8+ cell count, serum cholinesterase, and
       ALT were entered into the regression model as explanatory variables of
       the platelet count with statistical significance. A positive linear
       correlation in these 32 patients between the CD8+ cell count and
       platelet count (r = 0.50, P < 0.01) was noted. We conclude that the
       decrease of the CD8+ cell count may play a role in the pathogenesis of
       thrombocytopenia in Japanese hemophiliacs in the early stage of
       HIV-infection.
 DE    Adult  *CD8-Positive T-Lymphocytes
       Hemophilia/BLOOD/*COMPLICATIONS/VIROLOGY  Human  HIV
       Infections/*TRANSMISSION  HIV Seropositivity  Japan  Lymphocyte Count
       Male  Platelet Count  Regression Analysis  Retrospective Studies
       Thrombocytopenia/*ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

