       Document 0158
 DOCN  M9610158
 TI    Heterosexual transmission of HIV analysed by generalized estimating
       equations.
 DT    9601
 AU    Fielding KL; Brettle RP; Gore SM; O'Brien F; Wyld R; Robertson JR;
       Weightman R; MRC-BIAS, Centre for HIV Research, Edinburgh, U.K.
 SO    Stat Med. 1995 Jun 30;14(12):1365-78. Unique Identifier : AIDSLINE
       MED/96055703
 AB    A longitudinal analysis of a partner study is compared with a
       cross-sectional analysis which identify behavioural and biological risk
       factors for heterosexual transmission of HIV. Using generalized
       estimating equations (GEEs) a random effects logistic model is used for
       the longitudinal analysis. These approaches are illustrated by the
       Edinburgh heterosexual partner study. The longitudinal analysis finds
       that 'high-risk' sexual practices, unprotected intercourse for HIV and a
       low CD4 count in the index case significantly increase the risk of HIV
       transmission. The cross-sectional analysis, however, only indicates
       'high-risk' sexual practices as favourable for HIV transmission.
 DE    Adolescence  Adult  Cross-Sectional Studies  CD4 Lymphocyte Count
       Female  Human  HIV Infections/EPIDEMIOLOGY/*TRANSMISSION  *Logistic
       Models  Longitudinal Studies  Male  Middle Age  Risk Factors  Scotland
       *Sex Behavior  *Sexual Partners  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

