       Document 0137
 DOCN  M9610137
 TI    T cell awareness of paternal alloantigens during pregnancy.
 DT    9601
 AU    Tafuri A; Alferink J; Moller P; Hammerling GJ; Arnold B; Tumor
       Immunology Program, Deutsches Krebsforschungszentrum; (DKFZ),
       Heidelberg, Germany.
 SO    Science. 1995 Oct 27;270(5236):630-3. Unique Identifier : AIDSLINE
       MED/96042621
 AB    During pregnancy a semiallogeneic fetus survives despite the presence of
       maternal T cells specific for paternally inherited histocompatibility
       antigens. A mouse transgenic for a T cell receptor recognizing the major
       histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T
       cells reactive to paternal alloantigens. In contrast to syngeneic and
       third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus
       had reduced numbers of Kb-reactive T cells and accepted Kb-positive
       tumor grafts. T cell phenotype and responsiveness were restored after
       delivery. Thus, during pregnancy maternal T cells acquire a transient
       state of tolerance specific for paternal alloantigens.
 DE    Animal  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Fathers  Female  Fetus/*IMMUNOLOGY  Graft
       Rejection  H-2 Antigens/*IMMUNOLOGY  *Immune Tolerance  Male  Mice
       Mice, Inbred C57BL  Mice, SCID  Mice, Transgenic  Neoplasm
       Transplantation  Phenotype  Placenta/IMMUNOLOGY  Pregnancy  Pregnancy,
       Animal/*IMMUNOLOGY  Receptors, Antigen, T-Cell/IMMUNOLOGY  Support,
       Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

