       Document 0083
 DOCN  M9610083
 TI    Immunosuppression by a noncytolytic virus via T cell mediated
       immunopathology. Implication for AIDS.
 DT    9601
 AU    Zinkernagel RM; University of Zurich, Institute of Experimental
       Immunology,; Switzerland.
 SO    Adv Exp Med Biol. 1995;374:165-71. Unique Identifier : AIDSLINE
       MED/96047246
 AB    HIV is basically a non- or poorly cytocidal virus. Therefore, HIV
       infections in humans represent an apparent perversity in the balance
       between the host immune system and infectious agent: This noncytopathic
       virus infects macrophages, antigen presenting cells, helper T cells and
       other host cells which are then destroyed by the CD8+ T cell immune
       response. Thus, HIV infects some of the key cells involved in immune
       reactions and therefore induces the immune system to destroy itself and
       thereby enables the virus to persist. Accordingly, immunosuppression is
       not a cause of HIV cytopathogenicity but a consequence of conventional T
       cell mediated immunopathology that destroys macrophages antigen
       presenting cells, T helper cells and facilitates infection by trivial
       intracellular parasites which eventually cause fatal disease. This
       immunopathological view of AIDS is testable and, if correct, impinges on
       rationales for AIDS prevention and treatment.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  CD4 Lymphocyte Count
       CD4-Positive T-Lymphocytes/PATHOLOGY  Human  HIV/*PHYSIOLOGY  *Immune
       Tolerance  Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY
       Titrimetry  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

