       Document 0079
 DOCN  M9610079
 TI    AIDS as immune system activation. Key questions that remain.
 DT    9601
 AU    Ascher MS; Sheppard HW; Krowka JF; Bremermann HJ; Viral and Rickettsial
       Disease Laboratory, California Department; of Health Services, Berkeley
       94704, USA.
 SO    Adv Exp Med Biol. 1995;374:203-10. Unique Identifier : AIDSLINE
       MED/96047249
 AB    Immune system activation is gaining attention as a central part of HIV
       pathogenesis. Although there is no consensus yet as to the source of the
       signal or the result of the signalling, this line of thinking represents
       a significant shift in the paradigm away from considering HIV disease
       like any other cytopathic viral infection. Hopefully, completion of
       studies focussed on this approach will lead to more complete
       understanding of AIDS and more effective therapies, and will at least
       bring to the fore some of the central unanswered questions in modern
       cellular immunology.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/THERAPY  Animal
       Antigens, CD4/BLOOD  Apoptosis/IMMUNOLOGY  Human  Immune
       System/*PHYSIOPATHOLOGY  *Lymphocyte Transformation  Regeneration
       Signal Transduction/IMMUNOLOGY  Superantigens/BLOOD  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

