       Document 0078
 DOCN  M9610078
 TI    Inhibition of T lymphocyte activation and apoptotic cell death by
       cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV
       infection.
 DT    9601
 AU    Thomson AW; Bonham CA; Pittsburgh Transplantation Institute, University
       of Pittsburgh; Medical Center, Pennsylvania 15213, USA.
 SO    Adv Exp Med Biol. 1995;374:211-6. Unique Identifier : AIDSLINE
       MED/96047250
 AB    Theoretically, drugs that inhibit programmed cell death could be used to
       inhibit the increased apoptotic decay of lymphocyte populations in human
       immunodeficiency virus (HIV) infection. The concept that
       immunopathologic processes cause immune suppression provides a further
       rationale for the use of agents such as cyclosporin A (CsA) or
       tacrolimus (formerly known as FK506) early in HIV infection to reduce
       cytotoxic CD8+ T cell-mediated destruction of HIV-infected target cells.
 DE    Animal  Apoptosis/*DRUG EFFECTS/IMMUNOLOGY  Clinical Trials
       Cyclosporine/*PHARMACOLOGY  Human  HIV/PHYSIOLOGY  HIV Infections/*DRUG
       THERAPY/IMMUNOLOGY/PATHOLOGY  Immunosuppressive Agents/*PHARMACOLOGY
       Lymphocyte Transformation/*DRUG EFFECTS  Tacrolimus/*PHARMACOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

