       Document 0061
 DOCN  M9610061
 TI    Comparison of methods of estimating the mother-to-child transmission
       rate of human immunodeficiency virus type 1 (HIV-1). New York City
       Perinatal HIV Transmission Collaborative Study Group.
 DT    9601
 AU    Matheson PB; Weedon J; Cappelli M; Abrams EJ; Shaffer N; Bamji M;
       Krasinski K; Lambert G; Kaul A; Grimm K; et al; Medical and Health
       Research Association of New York City, Inc.,; NY.
 SO    Am J Epidemiol. 1995 Oct 1;142(7):714-8. Unique Identifier : AIDSLINE
       MED/96009973
 AB    Four methods of estimating mother-to-child transmission rates of human
       immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop,
       were compared in a multicenter New York City prospective cohort study in
       1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388
       were born HIV-1 seropositive and 445 were HIV-1 seronegative. The four
       methods, the Antibody Only, Indirect, Direct, and Virologic Methods,
       yielded transmission rate estimates of 19-25%, classifying 59-89% of the
       cohort. Estimation based on persistence of HIV-1 antibody and clinical
       assessment yielded transmission rates similar to those methods that
       incorporated virologic testing.
 DE    Adult  Blotting, Western  Child, Preschool  Comparative Study  Data
       Interpretation, Statistical  *Disease Transmission, Vertical  Female
       Human  HIV Infections/BLOOD/EPIDEMIOLOGY/*TRANSMISSION/VIROLOGY  *HIV-1
       Infant  Infant, Newborn  New York City/EPIDEMIOLOGY  Polymerase Chain
       Reaction  Pregnancy  *Pregnancy Complications,
       Infectious/BLOOD/EPIDEMIOLOGY/VIROLOGY  Prospective Studies
       Seroepidemiologic Methods  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

