       Document 0055
 DOCN  M9610055
 TI    Thrombocytopenia in pregnant women who use cocaine.
 DT    9601
 AU    Kain ZN; Mayes LC; Pakes J; Rosenbaum SH; Schottenfeld R; Department of
       Anesthesiology, Yale University School of Medicine,; Yale-New Haven
       Hospital, CT 06510, USA.
 SO    Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):885-90. Unique Identifier :
       AIDSLINE MED/96013410
 AB    OBJECTIVE: Our purpose was to determine the prevalence of
       cocaine-associated thrombocytopenia. STUDY DESIGN: This cohort study was
       conducted in an inner-city prenatal center. A total of 1907 patients
       were screened by the Mother's Project, which is an intervention project
       for inner-city cocaine-abusing parturients. Platelet counts were grouped
       by illicit drug usage. RESULTS: Platelet counts were available in 37%
       (709) of subjects; there were no differences between subjects with
       available platelet counts and those without on illicit drug use or other
       demographic measures. Five groups were defined: drug-free group (n =
       331), cocaine group (n = 104), cocaine and opiates group (n = 11),
       opiates group (n = 18), and other-drug group (n = 236). Nineteen
       subjects had a low platelet count (< 150 x 10(9)/L). The medical records
       of all subjects with a low platelet count were reviewed for any medical
       condition known to be associated with thrombocytopenia, and two subjects
       were excluded. The rate of thrombocytopenia in the drug-free group was
       1.5%, whereas the rate in the cocaine group was 6.7% (relative risk 4.4,
       p < 0.05). Because of the reported association of thrombocytopenia with
       seropositive human immunodeficiency virus status, seropositive women
       were excluded from the analysis. Even after human immunodeficiency virus
       status adjustments for the estimated rate, the cocaine-using group
       continued to have a significantly higher rate of thrombocytopenia (5.4%
       to 7.2% vs 1.23% to 1.26%, p < 0.05 to p < 0.005). CONCLUSIONS: These
       results indicate that cocaine use is an independent risk factor for
       thrombocytopenia in an inner-city parturient population.
 DE    Adult  Cesarean Section  Cocaine/*ADVERSE EFFECTS  Cohort Studies
       Female  Gestational Age  Human  HIV Seropositivity/COMPLICATIONS
       Pregnancy  Pregnancy Complications, Hematologic/*CHEMICALLY INDUCED
       Pregnancy Complications, Infectious  Risk Factors  Support, U.S. Gov't,
       P.H.S.  Thrombocytopenia/*CHEMICALLY INDUCED/COMPLICATIONS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

