       Document 0046
 DOCN  M9610046
 TI    Fetal alcohol and thymocyte phenotypes in offspring: response to food
       deprivation.
 DT    9601
 AU    Taylor AN; Tio DL; Chiappelli F; Department of Anatomy and Cell Biology,
       University of; California-Los Angeles School of Medicine 90024-1763,
       USA.
 SO    Alcohol Clin Exp Res. 1995 Jun;19(3):545-50. Unique Identifier :
       AIDSLINE MED/96028357
 AB    Restriction of food availability is a reliable stimulus that leads to
       significant hypothalamo-pituitary-adrenal (HPA) activation to which rats
       do not habituate. Based on our previous data that indicated that the HPA
       response to some, but not all, stressful stimuli is significantly
       greater in adult offspring of Sprague-Dawley dams exposed to 35% alcohol
       during the last 2 weeks of gestation than that of control rats and on
       the mounting neuroendocrine-immune literature that describes the role of
       pituitary-adrenal products in modulating cellular immunity, we
       hypothesized that the outcomes of food restriction would be
       significantly more marked in fetal alcohol-exposed (FAE) offspring,
       compared with control rats. Data we report herein show that--whereas
       food restriction at 30-35 days of age produced significant changes in
       body weight, thymus weight-to-body weight ratio, adrenal weight-to-body
       weight ratio, plasma corticosterone levels, and in thymocyte number, as
       well as in the percentage and absolute number of CD4+ and CD8+
       thymocytes that express CD45RC-FAE and control rats were equally
       affected. We conclude that food restriction is another example of a
       stressful stimulus that fails to distinguish satisfactorily between FAE
       and control rats of prepubertal age.
 DE    Animal  Arousal/PHYSIOLOGY  CD4-CD8 Ratio  Female  Fetal Alcohol
       Syndrome/*IMMUNOLOGY  Food Deprivation/*PHYSIOLOGY
       Hypothalamo-Hypophyseal System/PHYSIOLOGY  Immune Tolerance/IMMUNOLOGY
       Immunophenotyping  Lymphocyte Count  Male  Pituitary-Adrenal
       System/PHYSIOLOGY  Pregnancy  Rats  Rats, Sprague-Dawley  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

