       Document 0044
 DOCN  M9610044
 TI    Effects of chronic alcohol abuse and HIV infection on brain phosphorus
       metabolites.
 DT    9601
 AU    Meyerhoff DJ; MacKay S; Sappey-Marinier D; Deicken R; Calabrese G;
       Dillon WP; Weiner MW; Fein G; Department of Veterans Affairs Medical
       Center, Magnetic Resonance; Spectroscopy Unit, San Francisco, CA 94121,
       USA.
 SO    Alcohol Clin Exp Res. 1995 Jun;19(3):685-92. Unique Identifier :
       AIDSLINE MED/96028379
 AB    We examined the effects of human immunodeficiency virus (HIV) infection
       and chronic alcohol consumption on cerebral phosphorus metabolites to
       determine if chronic alcohol abuse is a risk factor for the progression
       of neurological effects of HIV infection. We studied 15 HIV- alcoholics,
       8 HIV- light/nondrinkers, 32 HIV+ alcoholics, and 41 HIV+
       light/nondrinking men, with both HIV+ groups having similar CD4
       lymphocyte counts. We used localized 31-phosphorus magnetic resonance
       spectroscopy after magnetic resonance imaging to examine two brain
       volumes in superior white matter and subcortical gray matter. Chronic
       alcohol consumption was associated with reduced white matter
       concentrations of phosphodiester (PDE) and phosphocreatine (PCr). Also
       in the white matter, acquired immune deficiency syndrome (AIDS) and
       AIDS-related complex (ARC) were associated with reduced concentrations
       of PDE and PCr, compared with both HIV- and clinically asymptomatic HIV+
       subjects. Because no alcohol-by-HIV interactions were detected, the
       effects of HIV infection and alcohol abuse were cumulative. This is
       reflected in a successive decrease of white matter PDE and PCr
       concentrations in the order HIV- light/nondrinkers/HIV- alcoholics/HIV+
       light/nondrinkers/HIV+ alcoholics. Subcortical gray matter PDE
       concentrations were lower in ARC/AIDS alcoholics than in HIV-
       light/nondrinking individuals. These findings suggest altered brain
       phospholipid metabolites and energy metabolites with alcohol abuse and
       HIV infection. They demonstrate that the adverse metabolic effects of
       HIV on the brain are augmented by chronic alcohol abuse.
 DE    Acquired Immunodeficiency Syndrome/PHYSIOPATHOLOGY  Adenosine
       Triphosphate/METABOLISM  Adult
       Alcoholism/COMPLICATIONS/*PHYSIOPATHOLOGY  AIDS Dementia
       Complex/*PHYSIOPATHOLOGY  AIDS-Related Complex/PHYSIOPATHOLOGY
       Brain/PATHOLOGY/*PHYSIOPATHOLOGY  Brain Mapping  Human  HIV
       Seropositivity/*PHYSIOPATHOLOGY  Magnetic Resonance Imaging  Male
       Middle Age  *Nuclear Magnetic Resonance  Phosphocreatine/METABOLISM
       Phosphoric Acid Esters/METABOLISM  Phosphorus/*METABOLISM  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

