       Document 0026
 DOCN  M9610026
 TI    Drug interactions with zidovudine phosphorylation in vitro.
 DT    9601
 AU    Hoggard PG; Veal GJ; Wild MJ; Barry MG; Back DJ; Department of
       Pharmacology & Therapeutics, University of; Liverpool, United Kingdom.
 SO    Antimicrob Agents Chemother. 1995 Jun;39(6):1376-8. Unique Identifier :
       AIDSLINE MED/96012205
 AB    We have investigated the effect of a range of drugs (some commonly
       coadministered with zidovudine [ZDV] to human immunodeficiency
       virus-positive patients) on intracellular phosphorylation of ZDV by
       stimulated peripheral blood mononuclear cells, Molt 4 cells, and U937
       cells in vitro. Of the drugs tested (azoles, antiviral agents,
       antibiotics, and anticancer agents), only doxorubicin and ribavirin
       caused inhibition of anabolite formation as measured by high-performance
       liquid chromatography. This in vitro approach may provide important
       leads to potential interactions at the phosphorylation level in patients
       with human immunodeficiency virus disease. It is reassuring that so many
       commonly administered drugs do not alter ZDV phosphorylation.
 DE    Antibiotics/METABOLISM  Antineoplastic Agents/METABOLISM  Antiviral
       Agents/METABOLISM  Azoles/METABOLISM  Cells, Cultured  Drug Interactions
       In Vitro  Phosphorylation  Support, Non-U.S. Gov't
       Zidovudine/*METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

