       Document 0010
 DOCN  M9610010
 TI    Reduced CD8+ peripheral blood T lymphocytes in rapidly progressive
       periodontitis.
 DT    9601
 AU    Nagasawa T; Nitta H; Watanabe H; Ishikawa I; Department of
       Periodontology, Faculty of Dentistry, Tokyo Medical; and Dental
       University, Japan.
 SO    Arch Oral Biol. 1995 Jul;40(7):605-8. Unique Identifier : AIDSLINE
       MED/96022365
 AB    The peripheral blood T-cell phenotype of patients with rapidly
       progressive periodontitis (RPP) was determined in order to investigate
       whether there were T-cell imbalances or not. Twenty patients aged 21-39
       yr were selected for this study. Bone resorption and probing pocket
       depth were measured. All the patients had 10 or more teeth showing bone
       loss of 50% or more. As controls, 12 periodontally healthy, age-matched
       individuals were selected. Blood samples were obtained by venipuncture,
       and lymphocytes were isolated. Two-colour flow cytometric analysis was
       done with monoclonal antibodies against human CD4, CD8, and CD45RA
       antigens. The RPP patients were found to have significantly lower
       percentage of CD8+ T cells (Mann-Whitney's U-test, p < 0.01) and an
       increased CD4/CD8 ratio (Mann-Whitney's U-test, p < 0.01) compared with
       healthy individuals. On the other hand, there were no significant
       differences in the percentages of CD4+ T cells and CD4+ CD45RA+ T cells
       between RPP patients and healthy individuals. No correlations between
       the clinical findings and T-cell subsets were found. These findings
       suggest that imbalances of peripheral blood T lymphocytes, especially a
       tendency to decreased CD8 + T cells, exist in RPP patients, and that
       cellular immune responses mediated by CD8 + T cells may play a part in
       the pathogenesis of RPP.
 DE    Adult  Antigens, CD45/BLOOD  Case-Control Studies  Cell Separation
       CD4-CD8 Ratio  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female  Flow
       Cytometry  Human  Male  Periodontitis/BLOOD/*IMMUNOLOGY  Reference
       Values  Statistics, Nonparametric  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

