       Document 0007
 DOCN  M9610007
 TI    Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance
       and AIDS.
 DT    9601
 AU    Dhein J; Walczak H; Westendorp MO; Baumler C; Stricker K; Frank R;
       Debatin KM; Krammer PH; Tumorimmunology Program, German Cancer Research
       Center,; Heidelberg.
 SO    Behring Inst Mitt. 1995 Jun;(96):13-20. Unique Identifier : AIDSLINE
       MED/96055888
 AB    The cell surface molecule APO-1/Fas(CD95), a member of the Tumor
       Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor
       superfamily mediates apoptosis upon cross-linking by agonistic
       antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95)
       and its ligand are the key molecules for antigen receptor-induced
       apoptosis in activated mature T cells. Here we propose a mechanism for
       antigen receptor-induced apoptosis of activated T cells via APO-1 ligand
       mediated autocrine suicide. This mechanism may also contribute to the
       depletion of CD4+ T cells in AIDS.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Animal  Antigens,
       CD/GENETICS/IMMUNOLOGY/*PHYSIOLOGY  Antigens,
       CD95/GENETICS/IMMUNOLOGY/*PHYSIOLOGY  *Apoptosis  Autoimmune
       Diseases/GENETICS/IMMUNOLOGY  Human  *Immune Tolerance  Models,
       Immunological  Mutation  Receptors, Nerve Growth Factor/PHYSIOLOGY
       Receptors, Tumor Necrosis Factor/PHYSIOLOGY  T-Lymphocytes/*IMMUNOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

