       Document 0005
 DOCN  M9610005
 TI    Differential antiviral activity of derivatized dextrans.
 DT    9601
 AU    Neyts J; Reymen D; Letourneur D; Jozefonvicz J; Schols D; Este J; Andrei
       G; McKenna P; Witvrouw M; Ikeda S; et al; Rega Institute for Medical
       Research, Katholieke Universiteit; Leuven, Belgium.
 SO    Biochem Pharmacol. 1995 Sep 7;50(6):743-51. Unique Identifier : AIDSLINE
       MED/96021070
 AB    The antiviral activity of water-soluble dextrans derivatized with
       varying percentages of carboxymethyl, benzylamide, and sulfonate groups
       was evaluated. Several of the polymers exhibited potent antiviral
       activity against a variety of enveloped viruses, but not against
       non-enveloped viruses, and only when present during virus adsorption.
       The mechanism of activity against retroviruses [i.e. human
       immunodeficiency virus (HIV)] and herpes viruses (i.e. human
       cytomegalovirus) could be ascribed to inhibition of virus binding to the
       cells. An absolute requirement for anti-HSV activity appeared to be a
       sufficiently high percentage of benzylamide and benzylamide sulfonate
       groups. This did not, however, apply for human cytomegalovirus,
       respiratory syncytial virus, and HIV. The sensitivity of the latter
       viruses appeared to be influenced by factors other than the global
       chemical composition, which leads us to assume that physical factors
       such as the distribution and sequence of the substituents on the sugar
       backbone play an important role in the antiviral activity of the
       derivatized dextrans.
 DE    Antiviral Agents/*CHEMICAL SYNTHESIS  Cell Line  Comparative Study
       Cytomegalovirus/DRUG EFFECTS  Dextrans/CHEMISTRY/*CHEMICAL
       SYNTHESIS/TOXICITY  HIV/DRUG EFFECTS  Respiratory Syncytial Viruses/DRUG
       EFFECTS  Simplexvirus/DRUG EFFECTS  Structure-Activity Relationship
       Support, Non-U.S. Gov't  Vesicular Stomatitis-Indiana Virus/DRUG EFFECTS
       Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

